The oxidation of the purine ring can occur while it is still in nucleotide combination or nucleoside combination. Biosynthesis of Purine Nucleotides: There are two pathways by which nucleotides are made available for the formation of nucleic acids: (1) Denovo synthesis i.e. In acidic urine the undissociated form of uric acid predominates and is poorly soluble, leading to crystalluria and stone formation. By I. Russel Lee (129264), Liting Yang ...

While degradation of purines to uric acid is generally conserved among organisms, the end product of uric acid catabolism varies among taxa often due to the loss of functional catabolic enzymes in the pathway.

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